Changes

  | autore5 = Staderini EM

  | autore5 = Staderini EM

  | autore6 = Scarnati E

  | autore6 = Scarnati E

  | titolo = Unilateral lesions of the pedunculopontine nucleus do not alleviate subthalamic nucleus-mediated anticipatory responding in a delayed sensorimotor task in the rat

  | titolo = Unilateral lesions of the pedunculopontine nucleus do not alleviate subthalamic nucleus-mediated anticipatory responding in a delayed sensorimotor task in the rat

  | url =  

  | url =  

  | OCLC =  

  | OCLC =  

  }}</ref>}}

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The paradigmatic result, reverses the tendency to consider the masticatory system as a simple kinematic organ and goes well beyond the traditional mechanicistic procedure of Classical Gnathology.

The paradigmatic result, reverses the tendency to consider the masticatory system as a simple kinematic organ and goes well beyond the traditional mechanicistic procedure of Classical Gnathology.

This aspect also introduces a type of indeterministic profile of biological functions, in which the function of a system presents as a network of multiple related elements.  

This aspect also introduces a type of indeterministic profile of biological functions, in which the function of a system presents as a network of multiple related elements.  

In addition to interpreting the state of this system, it should be stimulated from the outside to analyse the evoked response, as it is typical of indeterministic systems. <ref>Lewis ER, MacGregor RJ.On indeterminism, chaos, and small number particle systems in the brain. J Integr Neurosci. 2006 Jun;5(2):223-47.  https://www.ncbi.nlm.nih.gov/pubmed/?term=On+indeterminism,+chaos,+and+small+number+particle+systems+in+the+brain.</ref>     

In addition to interpreting the state of this system, it should be stimulated from the outside to analyse the evoked response, as it is typical of indeterministic systems. <ref>{{Cite book

Lewis ER, MacGregor RJ.On indeterminism, chaos, and small number particle systems in the brain. J Integr Neurosci. 2006 Jun;5(2):223-47.  https://www.ncbi.nlm.nih.gov/pubmed/?term=On+indeterminism,+chaos,+and+small+number+particle+systems+in+the+brain.</ref>     

It is, therefore, essential to switch from a simple and linear model of dental clinic to a Stochastic Complex  model of masticatory neurophysiology.     

It is, therefore, essential to switch from a simple and linear model of dental clinic to a Stochastic Complex  model of masticatory neurophysiology.     

To confirm this, in a study conducted among mice, the neurons in the Central Amigdaloide nucleus (ACe) were marked after the injection of a retrograde tracer(Fast Blue), in the caudal nucleus of the Me5, indicating that the Amigdaloians send direct projections to the Me5, and suggest that the amygdala regulates the strength of the bite by modifying the neuronal activity in the Me5 through a neural facilitation..<ref>Shirasu, M., et al., ''Direct projections from the central amygdaloid nucleus to the mesencephalic trigeminal nucleus in rats.'' Brain Res, 2011. 1400: p. 19-30.https://www.ncbi.nlm.nih.gov/pubmed/?term=Direct+projections+from+the+central+amygdaloid+nucleus+to+the+mesencephalic+trigeminal+nucleus+in+rats.+Brain+Res%2C+2011</ref>  

To confirm this, in a study conducted among mice, the neurons in the Central Amigdaloide nucleus (ACe) were marked after the injection of a retrograde tracer(Fast Blue), in the caudal nucleus of the Me5, indicating that the Amigdaloians send direct projections to the Me5, and suggest that the amygdala regulates the strength of the bite by modifying the neuronal activity in the Me5 through a neural facilitation..<ref>Shirasu, M., et al., ''Direct projections from the central amygdaloid nucleus to the mesencephalic trigeminal nucleus in rats.'' Brain Res, 2011. 1400: p. 19-30.https://www.ncbi.nlm.nih.gov/pubmed/?term=Direct+projections+from+the+central+amygdaloid+nucleus+to+the+mesencephalic+trigeminal+nucleus+in+rats.+Brain+Res%2C+2011</ref>  

Modifying occlusal ratios can alter oral somatosensory functions and the rehabilitative treatments of the Masticatory system should restore somatosensory functions. However, it is unclear why some patients fail to adapt to the masticatory restoration, and sensomotor disorders remain. At first, they would seem to be structural changes, not just functional ones. The primary motor cortex of the face<ref name=":1" /> is involved in the generation and control of facial gold movements and sensory inputs or altered motor functions, which can lead to neuroplastic changes in the M1 cortical area. <ref>Avivi-Arber, L., J.C. Lee, and B.J. Sessle, ''Dental Occlusal Changes Induce Motor Cortex Neuroplasticity.'' J Dent Res, 2015. 94(12): p. 1757-64. https://www.ncbi.nlm.nih.gov/pubmed/?term=Dental+Occlusal+Changes+Induce+Motor+Cortex+Neuroplasticity.+J+Dent+Res%2C+2015</ref>

Modifying occlusal ratios can alter oral somatosensory functions and the rehabilitative treatments of the Masticatory system should restore somatosensory functions. However, it is unclear why some patients fail to adapt to the masticatory restoration, and sensomotor disorders remain. At first, they would seem to be structural changes, not just functional ones. The primary motor cortex of the face<ref name=":1" /> is involved in the generation and control of facial gold movements and sensory inputs or altered motor functions, which can lead to neuroplastic changes in the M1 cortical area. <ref>{{Cite book

| autore = Avivi-Arber L

| autore2 = Lee JC

| autore3 = Sessle BJ

| titolo = Dental Occlusal Changes Induce Motor Cortex Neuroplasticity

| url = https://journals.sagepub.com/doi/10.1177/0022034515602478

| opera = J Dent Res

| anno = 2015

}}</ref>

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